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Exploiting differences in the catalytic active site architecture would then facilitate the design of new inhibitors selective for each isozyme

doi: 10.1042/BJ20101317

Science, 236 (4799), 280285

Adult KI mice exhibit heightened susceptibility to SDS-induced anxiety To evaluate the behavioral consequences of aberrant CCK upregulation in NL3 R451C KI mice, we conducted a series of behavioral assays probing anxiety- and depression-related phenotypes, both before and after exposure to SDS

Glucosyltransferases, which catalyze the conjugation reaction, are very specific for UDPG although these enzymes are thought to possess broad substrate specificity for xenobiotics

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