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Chronic cerebral hypoperfusion (CCH) significantly decreases the expression of proteins such as P62, CTSD, and LAMP1, while increasing the expression of beclin-1, Parkin, and BNIP3, as well as the LC3-II/LC3-I ratio, and the release of cytochrome c from mitochondria to the cytoplasm

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ROS production and associated inflammation are closely related to aging and numerous chronic diseases as diabetes, cardiovascular atherosclerosis-related diseases (144, 145) and respiratory diseases, known risk factors for developing severe illness and death in patients with SARS-CoV-2 and COVID-19 disease