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Instead of mimicking gut hormones like GLP-1 medications or following a daily weight loss injection plan, it targets pathways that regulate fat storage, energy expenditure, and insulin sensitivity

Wang XX, Myakala K, Libby AB, Krawczyk E, Panov J, Jones BA, et al

IGF-1 reduces serum GH levels (via somatostatin negative feedback in the pituitary) which in turn suppresses GH actions in the liver, thus enhancing insulin actions in this organ [165]

10.1111/j.1365-2141.2009.07937.x 43 QuintanaA

proved aged mice doubled their running capacity

Distinct from classical GH signaling (experimental): Research suggests minimal stimulation of IGF-1 and limited activation of pathways typically driven by full-length growth hormone