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Bottom line: The GH biology is real

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The two-receptor approach is studied because GHRH and GHS-R1a signaling activate complementary but distinct intracellular pathways GHRHR primarily through Gs/cAMP/PKA, GHS-R1a primarily through Gq/PLC/IP3/Ca making the dual-agonist approach a useful research tool for studying somatotrope cell biology comprehensively

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doi: 10.1016/j.phymed.2016.07.008

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USA 68 , 10241027 (1971)

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Jackson collected news and commentary at The New York Times Samuel L

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Enhanced blood flow from angiogenesis supports both soft tissue and nerve healing

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