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Description
IGF-1 is the hormone or growth stimulating metabolite produced by the metabolism of HGH, and is responsible for the beneficial effects of elevated human growth hormone

The regulated microbiota is thought to affect host health by improving gut barrier functions, reducing LPS-induced inflammation or oxidative stress, and increasing bile acid production
Multidrug-resistant fungi

Hence, changes in intra-portal insulin levels need to be taken into consideration to correctly interpret the alterations in the GH/IGF-I axis in healthy and disease states as this helps the clinician in formulating the decision-making process of when and how to perform appropriate diagnostic work-up and whether to offer treatment to improve any accompanying metabolic consequences

Part 1: history and principles

Mech Ageing Dev (2020) 192:111385
