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However, optimal dosing depends on the specific tissue being investigated, the nature and severity of injury or condition, administration route, and treatment duration

| Central York) Tyler Royal (Soph
Time-dependent vascular actions of cannabidiol in the rat aorta

J Neurosci 29:13274

PI3K activates Akt and transports it into the plasma membrane, eventually leading to increased synthesis of cellular proteins and consequently enhancement of cellular growth and abrogation of autophagy

To complement these in vivo efforts, in vitro studies that examine the effects of perturbing ligand-receptor interactions in specific ostegenic cell types will be valuable in providing a more complete understanding of how IGFs elicit their biological effects
