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Stress management is another major factor

Fourth, investigating potential off-target effects and long-term consequences: Given O-GlcNAcylations regulatory role in numerous cellular processes, unintended effects in non-targeted proteins or cells could disrupt essential signaling pathways, leading to adverse outcomes

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In addition, polyphenols withdraw free radical species and activate antioxidant genes or enzymes [227]

By Chilcott J, Lloyd Jones M, Wight J, Forman K, Wray J, Beverley C, et al

Thus, future investigations should include more diverse cohorts to assess the universality of these conclusions