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10.1038/s41392-020-00411-4

Suggested content includes a rationale for and description of the scope and focus of the data search and identification strategy/ies including the nature of preliminary scoping and/or expert input, the overall literature screening strategy and more focused literature surveys to identify additional information (including e.g., key search terms, databases and time period searched, any tools used)

The biocompatibility, targeting, and release mechanisms of nanoparticles need to be further studied, and the safety and efficacy of CRISPR technology in periodontal therapy, especially in avoiding genetic variation, need to be further explored

Notably, the observed downregulation of Metallothionein-2 (Mt2) in the serum proteome results, a well-established inducible antioxidant and metal-chelating protein in serum, strongly supports the interpretation of reduced oxidative stress

doi: 10.1101/sqb.2012.76.010900

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