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ProFLG is synthesized in the granular layer of the epidermis as a polyprotein that contains 1012 repeating domains in humans (Gan et al., 1990) but 20 repeats in the mouse (Rothnagel and Steinert, 1990) and rat (Haydock and Dale, 1990)

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4.5.2 Autophagy modulators Chloroquine and hydroxychloroquine remain the most clinically tested autophagy inhibitors to date, due to their previous FDA approval as anti-malaria drugs

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These intracellular stress fibers help to polarize the fibroblast and orient the nucleus in the direction it is traveling
