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Approval: 2000 WARNING: LIFE THREATENING ADVERSE REACTIONS See full prescribing information for complete boxed warning

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Fonseca, T

Jeulin C, Soufir J, Marson J, Paquignon M, Dacheux J

In vivo, mice on a high-fat diet (HFD) supplemented with TMAO exhibited greater colonic mucosal damage, reduced tight junction proteins, and elevated inflammatory markers compared to those on HFD alone, supporting the notion that TMAO induces tissue injury
