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Bermejo P, Martin-Aragon S, Benedi J, Susin C, Felici E, Gil P, et al

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Systemic effects of long-term, higher-dose ICS: Adrenal suppression Decreased bone mineral density Increased risk of cataracts and glaucoma Oral corticosteroid systemic effects (more severe, especially with prolonged use): Osteoporosis, diabetes, hypertension, weight gain, mood changes Drug Interactions Theophylline is metabolized by the cytochrome P450 system (primarily CYP1A2), making it susceptible to many interactions: Ciprofloxacin inhibits CYP1A2 increases theophylline levels (toxicity risk) Rifampin induces CYP enzymes decreases theophylline levels (reduced efficacy) Beta-2 agonists and beta-blockers work in direct opposition

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[DOI] [PMC free article] [PubMed] [Google Scholar] 70.Jamnani A.N., Montazeri M., Mirzakhani M., Moosazadeh M., Haghighi M

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