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Studies proved that the elevated levels of TNF- and IL-1 in the prefrontal cortex and hippocampus caused a loss of integrity of cortical neurons and a reduction in hippocampal neuronal activity (Shi et al

Iron deficiency may contribute to compromised thyroid hormone synthesis, storage, and secretion due to decreased oxygen transport or by impairing heme-dependent thyroid peroxidase despite adequate iodine intake

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Under these stressed conditions, the NRF2 binding sites of the inactivated KEAP1 become saturated with old NRF2, which allows newly translated NRF2 to bypass KEAP1 binding, translocate to the nucleus, and activate ARE-dependent gene expression (135)

Several components of the host immune system are dramatically altered during SARS-CoV-2 infection and the extent of immune dysregulation is related to the worsening of COVID-19 and progression to death (5)