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1000 Genomes Project Consortium, Auton A, Brooks LD, Durbin RM, Garrison EP, Kang HM, et al

While directly measuring neuroprotection in living patients is technically unfeasible, alternative strategies, such as monitoring pro-inflammatory markers or neuroprotective cytokines in the plasma of patients receiving istradefylline, could offer valuable mechanistic insights and serve as surrogate indicators of therapeutic activity [485]

[DOI] [PMC free article] [PubMed] [Google Scholar] Balendiran GK, Dabur R, Fraser D

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The second mechanism involves the nuclear transcription factor NRF2 (nuclear factor erythroid 2-related factor 2), which governs the cell's antioxidant defense network

Before starting any new medical treatment, patients should carefully evaluate their options and consult with healthcare providers