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Nat Rev Drug Discovery 20:309325 Narita Y, Arakawa Y, Yamasaki F, Nishikawa R, Aoki T, Kanamori M, Nagane M, Kumabe T, Hirose Y et al (2019) A randomized, double-blind, phase III trial of personalized peptide vaccination for recurrent glioblastoma

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As reported in this review, since the liver diseases previously described have oxidative stress in common for their pathogenesis, it follows that the worsening of oxidative damage contributes to HCC development

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and replacing any deficient cellular components

Koniver largely stopped using it because patients experienced a day or two of significantly depressed mood after treatment