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B12 injections are one of the most requested quick fix treatments at wellness clinics, usually by patients hoping for more energy and a faster metabolism

NNMT (nicotinamide N-methyltransferase) is upregulated in adipose tissue during obesity and metabolic dysfunction, where it actively depletes NAD+ by converting nicotinamide into N-methyl-nicotinamide for excretion

Published Research on 5-Amino-1MQ Foundational DIO Mouse Study Neelakantan et al., Biochemical Pharmacology (2018) This paper introduced 5-Amino-1MQ as a selective and membrane-permeable small molecule inhibitor of NNMT and tested it in 3T3-L1 adipocytes and in male C57BL/6J mice maintained on a high-fat diet

The causal relation between vitamin B12 status and obesity warrants further investigation

In addition, WADAs publication of the Prohibited Association List shall not be considered as formal written, advance notice to Athletes or other Persons of an Athlete Support Persons disqualifying status and the potential consequence of Prohibited Association
