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The stress-induced KEAP1 conformational change leads to the release of the DLG motif from KEAP1, preventing NRF2 from ubiquitination by Cul3

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99 Additionally, GSTO1 has been allied with the age of onset for Alzheimer's disease

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GPX7 has been demonstrated to be downregulated and hypermethylated in gastric cancer, and its reconstitution suppresses tumor cell growth [25]