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Interaction of S100A7 with RAGE activates p38 MAPK (mitogen-activated protein kinase) and ERK (extracellular signal-regulated kinase) signaling pathways, leading to production of multiple inflammatory mediators involved in psoriasis, including IL-1, IL-1, IL-6, IL-8, TNF- (91, 92) ( Figure 3 )

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The strong and consistent association between lower levels of LH in men with lower levels of testosterone in this study suggests that secondary hypogonadism was a more common etiology than primary hypogonadism in our study population

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