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doi: 10.3109/01485018908986849 175 CostelloLCFranklinRB

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Otherwise, without therapy, these syndromes were commonly presented in rats with the permanent occlusion of major vessels (veins and/or arteries [18,19,20,22,23,24,25,26,27,28,29,30], peripherally and centrally), major intoxication (lithium, alcohol) [39,40], acute pancreatitis [37], myocardial infarction [37], and maintained intra-abdominal hypertension [31]

The prevalence of these conditions range between 2 and 6% of population [12]

Key Takeaways Cagrilintide is an amylin analog that suppresses appetite through pathways complementary tobut different fromGLP-1 agonists

Consequently, these models often insufficiently simulate the liver microenvironment, leading to discrepancies in drug metabolism and toxicity profiles and reducing their predictive accuracy for toxicological and pharmacological applications 7,8