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Subsequently, nucleus translocation of PARP1-dependent AIF interacts with macrophage migration inhibitory factor (MIF) to format the AIF-MIF complex, which further induces the DNA breakage and ultimately results in parthanatos [140]

doi: 10.1016/j.tcb.2022.05.005 117 ZhouWLiuMLiXZhangPLiJZhaoY

Without targeted interventions to restore mitochondrial transport pathways and quench this raging oxidative fire, patients remain trapped in a devastating state of chronic cellular depletion and systemic hyper-reactivity, unable to break the cycle of fatigue and inflammation

PMID: 17489712

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