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Treating B12 Deficiency If you have diabetes, use metformin, and have vitamin B12 deficiency, your doctor has two major options to help get your levels back into a safe range, according to research in the World Journal of Diabetes : Intramuscular Injections You might need injections every one to two days at first, gradually tapering off to injections every three to four weeks

Toxicology assessments in rats found no organ toxicity at doses up to 10 mg/kg (approximately 1000x the effective dose), no mutagenicity in Ames testing, and no teratogenic effects

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Dexamethasone reduces the connective-tissue inflammation that drives fluid leakage, while hydrochlorothiazide increases urine production to remove fluid that has already accumulated, producing a combined anti-oedematous effect

Psychiatric and Behavioral Changes: Early psychiatric symptoms may include: Depression Anxiety Irritability Mood swings Cognitive decline Because psychiatric changes can precede liver symptoms, diagnosis is sometimes delayed