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Um, I would say if you wanted to play devil's advocate, the big thing is long-term safety, right

10.1038/s41598-018-31877-6 Summary Keywords atherosclerosis, cell metabolism, glycolysis, fatty acids, diabetes, comorbidity Citation Dai Y, Junho CVC, Schieren L, Wollenhaupt J, Sluimer JC, van der Vorst EPC and Noels H (2024) Cellular metabolism changes in atherosclerosis and the impact of comorbidities

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