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Moderate ROS levels can support survival and proliferation by activating signaling pathways that can contribute to tumor growth in stressful tumor microenvironments (Fig
The healthcare systems vary across countries, and nutritional deficiencies such as folate, iron, and zinc coexist with B12 deficiency in some parts of the world, suggesting that country-specific recommendations might still be useful, especially in settings with low resources

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10.1111/j.1365-3083.2011.02536.x 53
