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Since reversal of glutathione depletion by the amino acid precursor, N -acetylcysteine (NAC), is therapeutic in SLE, its mechanism of impact on the metabolome was examined within the context of a double-blind placebo-controlled trial

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All three published full-paper human studies include Edwin Lee as lead author

In these reactions, -KG is oxidized to succinate, and increasing levels of succinate can suppress the progression of -KG-dependent histone or DNA demethylase reactions 98