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The protein, fat, and carbohydrate ratio (%) based on calories was 21:14:65
doi: 10.1159/000488717
Biochemically, affected individuals have up to a three-fold increase in -N-trimethyllysine and reduced levels of -hydroxy-N--trimethyllysine and -butyrobetaine in both plasma and urine, with a high -N-trimethyllysine/-butyrobetaine ratio [164, 165, 167]
A 2015 meta-analysis of 4 RCTs (n=523) found ALC significantly reduced VAS pain scores compared to placebo (MD 1.20 points on 0-10 scale
152 Humans with mutations in both alleles of either leptin or the leptin receptor are obese, but these homozygous mutations are extremely rare
It may also contribute to lean muscle building, although the evidence supporting these claims has been inconsistent
