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54 using cohorts of 10 patients each

Molecules inhibiting one of the many steps in the apoptotic cascade are effective in protecting hair cells in vitro and, to some extent, in vivo [140,141]

Research has consistently illustrated that selenium amino acid derivatives, such as selenomethionine (SeMet) and methylselenocysteine (MSC), are capable of stimulating apoptosis in a broad spectrum of human solid tumors

In contrast, the vesicular transporter selectively concentrates glutamate into synaptic vesicles in a Na+-independent, ATP-dependent manner (Naito and Ueda, 1983, Tabb and Ueda, 1991, Fykse and Fonnum, 1996) that requires chloride (Tabb and Ueda, 1991, Fykse and Fonnum, 1996)