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AOD9604, by contrast, is a direct-acting peptide that mimics the fat-burning effects of growth hormone without actually increasing GH or IGF-1 levels

Additional complexity, and in accordance with IGF-1 secretion patterns, appeared when researchers found that IRS-1 was found more active in post-prandial states contrary to IRS-2 in fasting states [121]

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Scientific References Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial