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immune activation with targeting self-antigens, either due to infection-triggered impairment of regulatory T-cell function, molecular mimicry, dysregulation of the microbiotagutbrain axis, as well as permanent organ damage [104]

3.2.1 Nonalcoholic Fatty Liver Disease As a common nexus of a metabolic and hepatic disease, NAFLD is a clinical syndrome that involves lesions in the hepatic lobule, hepatic steatosis, and fat piling pathological features, despite no history of excessive alcohol consumption (Ni et al., 2020)

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