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Moreover, inflammatory mediators, such as Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) and Tumor necrosis factor-alpha (TNF-) increased, while pivotal proteins involved in dendritic and synaptic development, such as Synaptophysin (SYP), postsynaptic density protein 95 (PSD95) and brain-derived neurotrophic factor (BDNF) decreased in APP/PS1 mice

Both zinc deficiency (due to dietary insufficiency, malabsorption, or physiological stress) and zinc excess (from environmental pollution or feed oversupplementation) adversely affect health, disrupting mineral balance, enzyme function, and gut microbiota

In pregnancy, excessive inflammation is associated with major pregnancy-related complications such as preterm labor, placental thrombosis, placenta insufficiency, and developmental delays in neonates exposed to excessive inflammation before birth

The finding that TICs, rather than differentiated tumor cells, grow in 3D gels offers a unique opportunity to unveil TIC-specific signaling pathways and therapeutic targets common to various cancer types