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The neuroimaging literature is basically restricted to 1 H-MRS studies

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In response to the dopaminergic neural activation induced by substances of abuse, such as heroin (119, 120), methamphetamine (121, 122), and cocaine (123), the mitochondrial respiratory chain is rapidly activated, leading to mitochondrial dysfunction, such as decreased mitochondrial membrane potential, mitochondrial DNA, and mitochondrial proteins, and increased cytochrome c release, resulting in increased ROS and oxidative stress (124)

Jackson-Cook, G

The neuroprotective mechanisms may involve modulation of inflammatory responses within the central nervous system, promotion of neuronal survival, and enhancement of axonal regeneration and synaptic plasticity