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Individuals who passed the initial screening were invited to visit the clinic, where they provided informed consent and underwent a comprehensive eligibility screening

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Cho KS, Kwon KJ, Jeon SJ, Joo SH, Kim KC, Cheong JH, Bahn GH, Kim HY, Han SH, Shin CY, Yang SI

(2014) Prooxidant versus antioxidant brain action of ascorbic acid in well-nourished and malnourished rats as a function of dose: a cortical spreading depression and malondialdehyde analysis

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However, many countries have not approved Siveles for clinical use, due to the uncertainty of the randomised double-blind trial results