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Following activation of glutamate receptors, mitochondrial respiratory chain defects along with calcium overload and ROS accumulation seem to be the major routes that are induced, allowing the stimulation of apoptosis (91,92)

Our body produces this vital compound, but factors like stress, poor diet, and environmental toxins can deplete its levels

Glutathionylated proteins occur mainly in intracellular space because GSH is located in the cytoplasm and Cys residues of proteins are in a reduced form and able to form mixed disulfides

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doi: 10.18632/oncotarget.12461 114 MalekEJagannathanSDriscollJJ

Davis LG, Arentzen R, Reid JM, Manning RW, Wolfson B, Lawrence KL, Baldino F, Jr