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Quercetin prevents alterations of behavioral parameters, delta-aminolevulinic dehydratase activity, and oxidative damage in brain of rats in a prenatal model of autism

Creagan ET, Moertel CG, O'Fallon JR et al (1979) Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer

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The study authors note directly that this tissue accumulation is the source of long-term concern not acute poisoning, but the steady, dose-dependent loading of a neurotoxin into the brain, kidneys, liver, and other tissues over years of exposure