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Trends Immunol 2015, 36: 364373

Major Criteria Family history of vEDS with a documented causative variant in COL3A1 Arterial rupture at a young age Spontaneous sigmoid colon perforation in the absence of known diverticular disease or other bowel pathology Uterine rupture during the third trimester in the absence of previous C-section and/or severe peripartum perineum tears Carotid-cavernous sinus fistula (CCSF) formation in the absence of trauma Minor Criteria Bruising unrelated to identified trauma and/or in unusual sites such as the cheeks and back Thin, translucent skin with increased venous visibility Characteristic facial appearance Spontaneous pneumothorax Acrogeria Talipes equinovarus Congenital hip dislocation Hypermobility of small joints Tendon and muscle rupture Keratoconus Gingival recession and gingival fragility Early-onset varicose veins (under age 30 and starting before pregnancy if female) Arthrochalasia EDS (aEDS) If a person meets the diagnostic criteria for aEDS, genetic testing should be done to confirm the diagnosis

The ATP5G1 (also known as ATP5MC1) gene encodes the C1 protein, the ATP5MC2 (also known as ATP5G2) gene encodes the C2 protein, and the ATP5MC3 (also known as ATP5G3) gene encodes the C3 protein

The test is stopped if an adverse reaction occurs at any stage

With consistent use and a healthy lifestyle, many people begin to notice results within a few weeks

BPC 157 is used as a drug, food or dietary supplement