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As mitochondria are a central hub for energy production in neurons, they are particularly vulnerable to oxidative damage

All transients were measured at room temperature and data shown are the average of at least five traces

Any receptor that is stimulated continuously tends to become less responsive over time it down-regulates

Methylthioadenosine phosphorylase cDNA transfection alters sensitivity to depletion of purine and methionine in A549 lung cancer cells

Using high-throughput screening and orthogonal cell-based validation, we identified small-molecule inhibitors of the Munc13-4STX7 interaction, ENDOtollins (ENDOs)

We measured the total plasma glutathione S-transferase enzymatic activity level in the GSTM1 -null and -positive individuals