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However, although adenovirus-mediated NNT overexpression in mildly-trypsinised BL/6J islets fully restored the glucose regulation of islet NADPH/NADP + ratio and mitochondrial E GSH , it failed to significantly improve insulin secretion [33], raising doubts about a major role of NNT in GSIS

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10.1016/j.heliyon.2023.e22153 78 TzouvelekisA.KarampitsakosT.GomatouG.BourosE.TzilasV.ManaliE.et al (2020)

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The present study first explored the effect of carnitine supplementation on body weight in patients with PCOS, and in order to realize the optimal therapeutic effect, carnitine supplementation needs 250 mg/day for at least 14.4 weeks

doi: 10.1016/j.freeradbiomed.2004.03.010