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Cells were lysed by sonication, and lysate was clarified by centrifuging at 41,400 g for 30 min at 4 C

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Ingested PM with or without the associated xenobiotic toxicants can affect cells of the gastrointestinal tract, leading to inflammation and more severe issues like cancer development [55,56,57]

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DiNardo CD, Maiti A, Rausch CR, Pemmaraju N, Naqvi K, Daver NG, Kadia TM, Borthakur G , Ohanian M, Alvarado Y, Issa GC, Montalban-Bravo G, Short NJ, Yilmaz M, Bose P, Jabbour EJ, Takahashi K, Burger JA, Garcia-Manero G, Jain N, Kornblau SM, Thompson PA, Estrov Z, Masarova L, Sasaki K, Verstovsek S, Ferrajoli A, Weirda WG, Wang SA, Konoplev S, Chen Z, Pierce SA, Ning J, Qiao W, Ravandi F, Andreeff M, Welch JS, Kantarjian HM, Konopleva MY

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Findings from the MTHFR heterozygous data-set have not been discussed in detail in this manuscript due to the fact that correlates within this data-set occupied an overlapping position between the other two data sets

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The full name is des(1-3)IGF-1, meaning the first three N-terminal amino acids (glycine-proline-glutamate) have been cleaved off

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