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However, it is noteworthy that the senescent phenotype of RA FLS highly expresses CDKN2A and releases more pro-inflammatory mediators in response to TNF or oxidative stress stimuli to promote inflammation (87)

The delay in worsening functions followed the same dose-dependent trend

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Tomoeda, M., Inuzuka, M

These may include redness, swelling, itching, or tendernessand in rare cases, more severe irritation

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