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Unlike GLP-1 agonists such as semaglutide or tirzepatide, which work primarily through appetite suppression, AOD-9604 directly enhances fat metabolism at the cellular level through beta-3 adrenergic receptor modulation

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Concurrently, LPS treatment led to a significant decrease of approximately 19% in SOD activity, a crucial antioxidant enzyme

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10.1038/s41420-024-02278-8 40 CheD.XiaoY.ZhangX.ZhuK.ChenW.YouG.et al (2025)

doi: 10.1016/j.phrs.2013.12.005 27 LeinningerGMEdwardsJLLipshawMJFeldmanEL