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Type 2 Diabetes With Obesity# Recommendation : CagriSema Reason : REDEFINE 2 showed 13.7% weight loss with 73.5% of T2D patients achieving HbA1c of 6.5% or less, exceeding semaglutide's glycemic and weight results in T2D trials

Phosphorylation modification enhances DSIP activity The 7-serine residue of delta-sleep can be phosphorylated to generate P-DSIP, which has a biological activity 5-300 times higher than DSIP

For example, Sachdeva et al

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PubMed CrossRef Santa Ana EJ, LaRowe SD, Gebregziabher M, et al

Potential probiotic Lactobacillus rhamnosus (MTCC-5897) inhibits Escherichia coli impaired intestinal barrier function by modulating the host tight junction gene response