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The FDA classifies it as a Category 2 bulk drug substance, noting potential safety concerns in unregulated compounding

Petrovic et al., 2006)

Human safety data is limited

Its core physiological function is to catalyze the methylation of nicotinamide (NAM, a key precursor for NAD+ synthesis) with Sadenosylmethionine (SAM) to produce 1methylnicotinamide (1MNA)

Cumulatively, these data indicate that treatments aimed at increasing GSH levels in the brain may be a viable option for treatment and prevention of neurodegenerative disease

1b), exhibit strong affinity to Met with dissociation constants ( K D ) ranging from a few to 20 nM