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The hepatic enzyme acylpeptide hydrolase (APEH) facilitates conversion of VPAGLUC back to VPA, markedly impairing the drug's elimination and prolonging its half-life

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Hepatology 51 , 454462 (2010)

All study participants provided informed consent

LDH , lactate dehydrogenase

C (101 MHz, MeOD): 174.48 (C), 172.98 (C), 172.60 (C), 172.27 (C), 171.50 (C), 162.11 (q, J = 35.7 Hz, (C), 135.77 (t, J = 23.8 Hz, CD)), 134.37 (td, J = 25.0, 9.9 Hz, CD), 131.03 (td, J = 25.1, 12.5 Hz, CD), 119.69 (d, J = 86.2 Hz, C), 116.02 (q, J = 284.5 Hz, C) 54.03 (CH), 53.49 (CH), 41.81 (CH 2 ), 40.10 (CH 2 ), 36.20 (CH 2 ), 35.25 (CH 2 ), 32.35 (CH 2 ), 29.44 (CH 2 ), 28.70 (d, J = 16.9 Hz, CH 2 ), 27.05 (CH 2 ), 23.13 (d, J = 4.3 Hz, CH 2 ), 22.67 (d, J = 51.3 Hz, CH 2 )