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Ibuprofen, in particular, possesses Nf-kB inhibitory activity that may further help reducing excess inflammation/cytokine release in COVID-19 patients ( there is no evidence supporting the association between Ibuprofen and increased risk of severity of COVID-19 , a position strengthened by a systematic review appeared 2 months later ( Several studies are accumulating and reappraising the importance of NSAIDs in COVID-19 management ( in silico screenings independently identified the COX-II inhibitor celecoxib as a potential anti-SARS-CoV-2 drug, and a very recent study still under peer review reports its beneficial effects plus famotidine in hospitalized patients ( Despite this accumulating evidence, paracetamol (PAC) was suggested as a safer and recommendable alternative for the early and domiciliary management of pain and fever in COVID-19 patients

Future directions include the development of advanced drug delivery platforms, combinatory therapeutic regimens, and personalized medicine approaches integrating curcumin within multifaceted neurotherapeutic strategies

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Zip transporter ZIP7 (SLC39A7) is a newly discovered genetic determinant of ferroptosis that can trigger ERS and inhibit ferroptosis[53]

Post-fixation was performed with 1% osmium tetroxide (OsO 4 ) in 0.1 M PB for 2 h at room temperature, followed by three 15-min rinses in PB