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Additionally, stimulating Nrf2 plays a crucial role in blocking macrophage activation and their transformation into myofibroblasts, underscoring the importance of Nrf2 as a target in treatment approaches for lung fibrosis resulting from silica exposure [16, 17]

Oncogenic activation of AKT by mutant PI3KCA and mTORC2 signaling are common in cancers, and consequently xCT activity may be influenced by multiple posttranslational and metabolic inputs

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Nitrite, nitric oxide and oxygen control respiratory flux at genetic and metabolic levels