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In addition to the RTK-mediated activation, PLC PIP2 hydrolyzing activity can be also induced by the transmembrane spanning GPCR receptors [12]

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By the advice of Bute, who was the real head of the government, George set about "a reformation of the American charters." Secret agents were sent to travel in the different colonies, to procure access to the leading men, and to collect such information respecting the character and temper of the people as would enable ministers to judge what regulations and alterations could be safely made in the police and government of the colonies, in order to their being brought more effectually under the control of Parliament

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