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( ( ( ( ( After review of the information provided by the applicant, we have the following concerns regarding whether SER-109 meets the substantial clinical improvement criterion

42 , 162 , 163 , 164 , 165 IMiDs have also demonstrated improvements in daratumumabmediated ADCC in lenalidomiderefractory MM cells, while pomalidomide enhances isatuximabinduced ADCC in vitro and in vivo

doi: 10.1016/j.phrs.2021.105580 20 ZhangYXinLXiangMShangCWangYWangYet al

The primer pairs used for qRT-PCR were listed in Table S6

Oksala et al., 2009)

Fer-1, a commonly used ferroptotic inhibitor that can eliminate free radicals and lipid peroxides, has been tested in various diseases, including testicular dysfunction and cancer [82, 93, 126]