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For instance, iron transporters, lipid peroxidases, and inflammatory cytokines are key regulatory molecules in this pathway, collectively contributing to lipid peroxidation and ferroptosis ( Figure 1 In macrophages, ferroptosis is regulated by several interrelated pathways, including the Keap1-Nrf2, system Xc - /GSH/GPX4, FSP1-CoQ10-NAD(P)H, and GTP-GCH1-BH4 pathways ( lnc-MRGPRF-6:1 interfere with GPX4 function or modulate ferroptosis-related signaling pathways, facilitating lipid peroxidation and ferroptotic cell death (41) ( Figure 2 )

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M.R., Jacoby, S.M., Laterra, R., Harrop, J.S., Vaccaro A.R.., Hilibrand, A.S., Anderson, D.G., Albert, T.J.: Normal prevertebral soft tissue swelling following elective anterior cervical decompression and fusion

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