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For example, chelating agents may induce toxicity by binding with other metal ions while off-target effects make copper regulation using copper ion carriers difficult, thus additional studies on how to regulate copper levels are required (180)

Ejima R, Akiyama M, Sato H, Tomioka S, Yakabe K, Kimizuka T, et al

Cellular and molecular mechanisms of hepatic ischemia-reperfusion injury: The role of oxidative stress and therapeutic approaches

Future research should also aim to disentangle the mechanistic interplay between S accumulation, sirtuin dysregulation, and impaired insulin signaling in PD, to identify which phytomolecules are most effective in counteracting mitochondrial stress, mitophagy defects, and neuronal apoptosis

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