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Because they act on separate receptors (GHRH receptor vs GHS-R), combining them lets researchers study combined upstream GH-axis stimulation rather than a single pathway in isolation

doi: 10.3390/biom7020042

We simulated the effect of pifithrin- treatment by multiplying the phospho-p53-dependent production of p21 and MDM2 with k PFT = 0.5, and the amount of phospho-p53 and the phosphorylation rate of p53 with k PFT phos = 0.67 at the time of treatment, because the effect of pifithrin- causes approximately a 50% decrease in p53-dependent transcriptional activation 95 and a 33% decrease in phosphorylated p53 species 93

Otte, J., Dyberg, C., Pepich, A

The primary consequence of the enzymatic block is greatly reduced intracellular glutathione levels, usually less than 10% of normal levels

Babizhayev MA, et al