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Wennberg A, Hyltander A, Sjberg , et al

miR-98-5p prevents hippocampal neurons from oxidative stress and apoptosis by targeting STAT3 in epilepsy in vitro

MCMV triggers ROS/NLRP3-associated inflammasome activation in the inner ear of mice and cultured spiral ganglion neurons, contributing to sensorineural hearing loss

Medications that compete with phenytoin for binding to albumin (e.g., valproic acid)

Bioactivation A process by which a compound is converted to a metabolite that is more toxic then the original compoundalso known as toxification

Intralesional Medication Intralesional injection could deliver the agents into the pathological site with relative high concentration and avoid systemic side effects where possible