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However, substantial heterogeneity among studies was observed, likely attributable to differences in dosage, baseline B12 status, and population characteristics

For example, growth hormone is implicated in activating bone turnover, increasing body lean mass, and reducing adiposity

doi: 10.1146/annurev.cellbio.23.090506.123337 77

deHaart SJHolthofLNoortWAMinnemaMCEmmelotMEAarts-RiemensTet al

Fortunately, new medications now frequently prevent the progression of joint damage